How exactly does CBD work in the brain?

How exactly does CBD work in the brain?

To understand the mechanisms of action of CBD, it's important to know a bit about the endocannabinoid system (ECS). The ECS is a complex system of receptors and neurotransmitters found throughout the body, including the brain. It plays a crucial role in regulating various physiological processes, including pain, mood, and appetite.

The ECS is made up of two main types of receptors, CB1 and CB2. CB1 receptors are found mainly in the central nervous system, while CB2 receptors are found mainly in the peripheral nervous system. Both receptors interact with compounds called endocannabinoids, which are naturally produced by the body and bind to the receptors to regulate various functions.


CBD works in the brain by interacting with the endocannabinoid system. However, unlike THC, the psychoactive component of marijuana, CBD does not directly bind to the CB1 or CB2 receptors. Instead, it influences the activity of these receptors indirectly, by increasing the levels of endocannabinoids in the body and blocking their breakdown. This leads to an overall increase in the activity of the endocannabinoid system, which has been shown to have a number of therapeutic effects.

One of the ways in which CBD works in the brain is by reducing anxiety and depression. CBD has been shown to increase levels of the neurotransmitter serotonin, which is known to regulate mood and social behavior. By increasing the levels of serotonin, CBD can help to improve mood and reduce symptoms of anxiety and depression.

Another way in which CBD works in the brain is by reducing inflammation and pain. CBD has been shown to interact with the CB1 and CB2 receptors, which play a role in regulating pain perception. By reducing the activity of these receptors, CBD can help to reduce pain and inflammation.

CBD has also been shown to improve sleep. This may be due to its ability to reduce anxiety and improve mood, which can make it easier to fall asleep and stay asleep. Additionally, CBD has been shown to increase the levels of the neurotransmitter GABA, which is known to promote sleep.

Back to blog